In Vivo Assessment of Vesicular Monoamine Transporter Type 2 in Dementia With Lewy Bodies and Alzheimer Disease
Identifieur interne : 006A09 ( Main/Exploration ); précédent : 006A08; suivant : 006A10In Vivo Assessment of Vesicular Monoamine Transporter Type 2 in Dementia With Lewy Bodies and Alzheimer Disease
Auteurs : Victor L. Villemagne [Australie] ; Nobuyuki Okamura [Japon] ; Svetlana Pejoska [Allemagne] ; John Drago [Australie] ; Rachel S. Mulligan [Allemagne] ; Gaël Chetelat [France] ; Uwe Ackermann [Allemagne] ; Graeme O'Keefe [Allemagne] ; Gareth Jones [Allemagne] ; Sylvia Gong [Allemagne] ; Henry Tochon-Danguy [Allemagne] ; Hank F. Kung [États-Unis] ; Colin L. Masters [Australie] ; Daniel M. Skovronsky [États-Unis] ; Christopher C. Rowe [Allemagne]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: To assess the diagnostic potential of imaging striatal monoaminergic terminal integrity with the vesicular monoamine transporter type 2 (VMAT2) radioligand 18F 9-fluropropyl-(+)-dihydrotetrabenazine ([18F]AV-133) and positron emission tomography to distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD). Design, Setting, and Participants: Nine patients with DLB, 10 patients with AD, 20 patients with Parkinson disease (PD), and 10 healthy age-matched control subjects underwent [18F]AV-133 positron emission tomography studies. VMAT2 density was calculated through normalized tissue uptake value ratios at 120 to 140 minutes postinjection using the primary visual cortex as the reference region. Main Outcome Measure: Comparison of the tissue ratio for [18F]AV-133 between the different clinical diagnostic groups. Results: Lower VMAT2 densities were observed in patients with DLB when compared with patients with AD especially in the posterior putamen (caudate: mean [SD], 1.24 [0.6] vs 2.83 [0.9]; P<.001 ; effect size=2.1; anterior putamen: mean [SD], 0.90 [0.5] vs3.01 [0.9]; P < .001; effect size = 2.9; posterior putamen: mean [SD], 0.62 [0.5] vs 2.87 [0.8]; P < .001; effect size =3.4). Compared with healthy controls, [18F] AV-133 tissue ratios were significantly lower by 88% and 74% in the posterior putamen, 74% and 65% in the anterior putamen, and 53% and 51% in the caudate nucleus of patients with PD and DLB, respectively. In contrast to patients with PD and DLB, no reductions were observed in patients with AD. Conclusions: [18F]AV-133 allows assessment of nigrostriatal degeneration in Lewy body diseases. [18F]AV-133 can robustly detect reductions of dopaminergic nigrostriatal afferents in patients with DLB and assist in the differential diagnosis from AD.
Affiliations:
- Allemagne, Australie, France, Japon, États-Unis
- Bade-Wurtemberg, Basse-Normandie, District de Karlsruhe, Pennsylvanie, Région Normandie, Victoria (État)
- Caen, Heidelberg, Melbourne, Philadelphie
- Université de Melbourne
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Masters</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mental Health Research Institute, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Skovronsky, Daniel M" sort="Skovronsky, Daniel M" uniqKey="Skovronsky D" first="Daniel M." last="Skovronsky">Daniel M. 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Villemagne</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mental Health Research Institute, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Okamura, Nobuyuki" sort="Okamura, Nobuyuki" uniqKey="Okamura N" first="Nobuyuki" last="Okamura">Nobuyuki Okamura</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pharmacology, Tohoku University School of Medicine</s1><s2>Sendai</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Pejoska, Svetlana" sort="Pejoska, Svetlana" uniqKey="Pejoska S" first="Svetlana" last="Pejoska">Svetlana Pejoska</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Drago, John" sort="Drago, John" uniqKey="Drago J" first="John" last="Drago">John Drago</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Howard Florey Institute, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Neuroscience, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Mulligan, Rachel S" sort="Mulligan, Rachel S" uniqKey="Mulligan R" first="Rachel S." last="Mulligan">Rachel S. Mulligan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chetelat">Gaël Chetelat</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Inserm-Ecole Practique des Hautes Études-Université de Caen/Basse-Normandie</s1><s2>Caen</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Ackermann, Uwe" sort="Ackermann, Uwe" uniqKey="Ackermann U" first="Uwe" last="Ackermann">Uwe Ackermann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="O Keefe, Graeme" sort="O Keefe, Graeme" uniqKey="O Keefe G" first="Graeme" last="O'Keefe">Graeme O'Keefe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Jones, Gareth" sort="Jones, Gareth" uniqKey="Jones G" first="Gareth" last="Jones">Gareth Jones</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Gong, Sylvia" sort="Gong, Sylvia" uniqKey="Gong S" first="Sylvia" last="Gong">Sylvia Gong</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Tochon Danguy, Henry" sort="Tochon Danguy, Henry" uniqKey="Tochon Danguy H" first="Henry" last="Tochon-Danguy">Henry Tochon-Danguy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kung, Hank F" sort="Kung, Hank F" uniqKey="Kung H" first="Hank F." last="Kung">Hank F. Kung</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Radiology, University of Pennsylvania</s1><s3>USA</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Radiology, University of Pennsylvania</wicri:noRegion></affiliation></author><author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mental Health Research Institute, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Skovronsky, Daniel M" sort="Skovronsky, Daniel M" uniqKey="Skovronsky D" first="Daniel M." last="Skovronsky">Daniel M. Skovronsky</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Radiology, University of Pennsylvania</s1><s3>USA</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Radiology, University of Pennsylvania</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Avid Radiopharmaceuticals Inc</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Lewy body dementia</term><term>Nervous system diseases</term><term>Vesicular monoamine transporter</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence à corps de Lewy</term><term>Démence d'Alzheimer</term><term>Pathologie du système nerveux</term><term>Transporteur vésiculaire monoamine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To assess the diagnostic potential of imaging striatal monoaminergic terminal integrity with the vesicular monoamine transporter type 2 (VMAT2) radioligand <sup>18</sup>F 9-fluropropyl-(+)-dihydrotetrabenazine ([<sup>18</sup>F]AV-133) and positron emission tomography to distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD). Design, Setting, and Participants: Nine patients with DLB, 10 patients with AD, 20 patients with Parkinson disease (PD), and 10 healthy age-matched control subjects underwent [<sup>18</sup>F]AV-133 positron emission tomography studies. VMAT2 density was calculated through normalized tissue uptake value ratios at 120 to 140 minutes postinjection using the primary visual cortex as the reference region. Main Outcome Measure: Comparison of the tissue ratio for [<sup>18</sup>F]AV-133 between the different clinical diagnostic groups. Results: Lower VMAT2 densities were observed in patients with DLB when compared with patients with AD especially in the posterior putamen (caudate: mean [SD], 1.24 [0.6] vs 2.83 [0.9]; P<.001 ; effect size=2.1; anterior putamen: mean [SD], 0.90 [0.5] vs3.01 [0.9]; P < .001; effect size = 2.9; posterior putamen: mean [SD], 0.62 [0.5] vs 2.87 [0.8]; P < .001; effect size =3.4). Compared with healthy controls, [<sup>18</sup>F] AV-133 tissue ratios were significantly lower by 88% and 74% in the posterior putamen, 74% and 65% in the anterior putamen, and 53% and 51% in the caudate nucleus of patients with PD and DLB, respectively. In contrast to patients with PD and DLB, no reductions were observed in patients with AD. Conclusions: [<sup>18</sup>F]AV-133 allows assessment of nigrostriatal degeneration in Lewy body diseases. [<sup>18</sup>F]AV-133 can robustly detect reductions of dopaminergic nigrostriatal afferents in patients with DLB and assist in the differential diagnosis from AD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Japon</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Normandie</li><li>District de Karlsruhe</li><li>Pennsylvanie</li><li>Région Normandie</li><li>Victoria (État)</li></region><settlement><li>Caen</li><li>Heidelberg</li><li>Melbourne</li><li>Philadelphie</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name></region><name sortKey="Drago, John" sort="Drago, John" uniqKey="Drago J" first="John" last="Drago">John Drago</name><name sortKey="Drago, John" sort="Drago, John" uniqKey="Drago J" first="John" last="Drago">John Drago</name><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name></country><country name="Japon"><noRegion><name sortKey="Okamura, Nobuyuki" sort="Okamura, Nobuyuki" uniqKey="Okamura N" first="Nobuyuki" last="Okamura">Nobuyuki Okamura</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Pejoska, Svetlana" sort="Pejoska, Svetlana" uniqKey="Pejoska S" first="Svetlana" last="Pejoska">Svetlana Pejoska</name></region><name sortKey="Ackermann, Uwe" sort="Ackermann, Uwe" uniqKey="Ackermann U" first="Uwe" last="Ackermann">Uwe Ackermann</name><name sortKey="Gong, Sylvia" sort="Gong, Sylvia" uniqKey="Gong S" first="Sylvia" last="Gong">Sylvia Gong</name><name sortKey="Jones, Gareth" sort="Jones, Gareth" uniqKey="Jones G" first="Gareth" last="Jones">Gareth Jones</name><name sortKey="Mulligan, Rachel S" sort="Mulligan, Rachel S" uniqKey="Mulligan R" first="Rachel S." last="Mulligan">Rachel S. Mulligan</name><name sortKey="O Keefe, Graeme" sort="O Keefe, Graeme" uniqKey="O Keefe G" first="Graeme" last="O'Keefe">Graeme O'Keefe</name><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><name sortKey="Tochon Danguy, Henry" sort="Tochon Danguy, Henry" uniqKey="Tochon Danguy H" first="Henry" last="Tochon-Danguy">Henry Tochon-Danguy</name></country><country name="France"><region name="Région Normandie"><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chetelat">Gaël Chetelat</name></region></country><country name="États-Unis"><noRegion><name sortKey="Kung, Hank F" sort="Kung, Hank F" uniqKey="Kung H" first="Hank F." last="Kung">Hank F. Kung</name></noRegion><name sortKey="Skovronsky, Daniel M" sort="Skovronsky, Daniel M" uniqKey="Skovronsky D" first="Daniel M." last="Skovronsky">Daniel M. Skovronsky</name><name sortKey="Skovronsky, Daniel M" sort="Skovronsky, Daniel M" uniqKey="Skovronsky D" first="Daniel M." last="Skovronsky">Daniel M. Skovronsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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